ABSTRACT
Oxidative Modification of Blood Serum Proteins due to free radical stress has been studies in 65 patients Diabetes Mellitus [DM] and Myocardial Infarction [MI]. It has been shown that both DM and MI patients have increased level of Oxidatively Modified Human Serum Proteins [OMHSP] as compared to healthy persons. Diabetic patients had a significantly higher level and slower dynamic of OMHSP that non-diabetic patients did during 14 days after the onset of Acute MI. The data suggest that oxidative modification of proteins may be a possible factor contributing to the poorer outcome of MI in diabetic patients. The study was conducted in Cardiology and Medical units of Allama Iqbal Medical College /Jinnah Hospital Lahore during 2001-2002
Subject(s)
Humans , Free Radicals , Diabetes Mellitus , Myocardial Infarction , ProteinsABSTRACT
Oxidative Modification of Blood Proteins [OMBP] has been studied in 65 patients with Diabetes. Mellitus [DM] and Myocardial Infarction [MI]. It has been shown that both DM and MI patients have increased levels of OMBP as compared to healthy persons. Diabetic patients had significantly higher levels and slower dynamics of OMBP than non-diabetic patients did during 14 days after onset of Acute MI. These data suggest that Oxidative Modification of proteins is a possible factor contributing to the poorer outcome of MI in diabetic patients
ABSTRACT
The disturbance in the Geomagnetic Pole [GMP] may play a signal of change in Bioadaptive Mechanism leading to Ischemic Heart Disease [IHD]. The data of GMP from The Institute of Geophysics, Gottingen, Germany of 1097 days [1989-1992] were analysed and compared to the hospital admissions, 2635 patients with acute Myocardial Infarction [MI] in this period, in the Crimea Medical Institute, Cardiac Gentre, Simferopol-333006, Ukraine: a] The Geomagnetic Pole Disturbed Day [GMPDD] were 243 [22.2%] during which 568 patients [21.6% of the total patients with MI] were admitted. B] The unfavourable days [UFD, disturbed day, a day before and a day after the disturbed day] were 541 [49.3%] by the method of overlapping period, during which 1318 patients [50% of the total patients with MI] were admitted. It is the highest% age of admission as compared to the rest of the days. Hence, it is very wise to think that disturbance in GMP, may have been expressed as the aggravation of IHD. c] The number Sudden Geomagnetic Strom Days [SGSD] were 102 [9.3%] during which 257 patients [9.8%] were admitted
Subject(s)
Humans , Morbidity , Magnetics , Solar SystemABSTRACT
The analysis of 138 myocardial infarction [MI] cases has been carried out for the period of 366 days. The results were compared with prognostic and truly disturbed days when the geomagnetic pole was elevated [the data of Institute of Geophysics in Gottingen, Federal Republic of Germany were used]. Hemodynamic parameters and psychological status of the patients with MI were determined according to MMPI test. It was noted that greater number of persons fell ill when prognostic and truly disturbed days coincided. No considerable increase in MI morbidity was found only in disturbed days. Certain specific psychological profile prevailed in patients who fell ill in coincided days, disturbed days and prognostic days known and unknown to the patients. It is proposed that the human organism becomes more sensitive to the geomagnetic factors when psychological and physical deadaptation occurs. This is also reflected by the destabilization of regulatory system of the organism
Subject(s)
Humans , Male , Statistics, Nonparametric , Morbidity , Myocardial Infarction/diagnosis , Regression Analysis/methodsABSTRACT
The effect of mixed use of coenzymes, antihypoxic preparations and cytochrome C was studied in 20 patients with dilated cariomyopathy [DCMP]. Positive effect of relieving cardilogic syndrome [arrhythmia and cardiac failure] was observed with the administration of cobamide [vit. B12], pyridoxal phosphate [vit. B6] and ATP in combination with exogenic cytochrome C. Cytochemical data of oxidation-reduction process in blood lymphocytes before and after treatment differed with positive dynamics. This showed the high metabolic effect of these coenzymes from B-vitamins and antihypoxic substances in the DCMP patients
Subject(s)
Humans , Cardiomyopathies , Vitamin B Complex , Coenzymes , Cytochromes cABSTRACT
Cytochemical analysis and bioenergetics of blood lymphocytes have been studied in 68 patients of Infectious Allergical Myocarditis [IAM] and 44 patients of Myocardiosclerosis [MC]. Regarding cellular metabolism, the activity of Glucose-6-PO4 Dehydrogenase [G-6-PD] [E.C. I.I.I.49] was found to be high according to the Nitrobluetetrazolium Reduction Test [I] due to the disturbance of NAD and NADP diaphorase [E.C.I.6.4.3]. The activity of L-glycerophosphate Dehydrogenase [E.C.I.1.1.8, 1.1.99.5] and cytochrome C content of the cells was found to be reduced. Thus, study of energy metabolism of blood lymphocytes provides an additional differential characteristics of inflammatory injuries of myocardium